The 4th International Conference on Nursing

Author :

(1) Nadia Oktiffany Putri; (2) Dina Dewi Sartika Lestari Ismail; (2) Heri Kristianto

Affiliation :

(1) Master of Nursing, Universitas Brawijaya, Malang, Indonesia; (2) School of Nursing, Universitas Brawijaya, Malang, Indonesia

Abstract :

Introduction Celery (Apium graveolans) contains flavonoid called apigenin which has antioxidant activity. Flavonoid content, apigenin, has the ability as an antiulcer through the protection of gastric mucosa. The aim of this study was to determine the effect of celery ethanol extract to decrease ulcer index as preventive action of gastric ulcer. Methods This study was true experimental study with Post Control Only Control Group Design. Samples were divided into three groups treated by preventive therapy including celery ethanol extract with dose 200, 300, and 400 mg / kg of body weight for 5 days, then indomethacin induced. All data obtained from calculation formula of ulcer index and analyzed with One Way ANOVA statistical test with significance level 5%. Results Ethanol extract of celery in the three treatment groups had significant effect to decrease ulcer index. Based on Post Hoc test used Tukey HSD test, negative control group had significant difference compared to all groups. Between the treatment groups 1, 2, and 3 there was no significant difference in the results of the ulcer index. Conclusion It is indicated that celery ethanol extract has an effect to decrease ulcer index as preventive action of gastric ulcer.

Keywords :

Celery; Ulcer Index; Gastric Ulcer