The 4th International Conference on Nursing

Author :

[1] Heri Kristianto; [2] Fatika Maulidyah Yuwanto; [2] Rifqa Ghina Mufida

Affiliation :

[1] Medical Surgical Nursing Department, School of Nursing, Universitas Brawijaya, Malang, Indonesia; [2] Undergraduate Student, School of Nursing, Universitas Brawijaya, Malang, Indonesia

Abstract :

Introduction Impaired wound healing process is one of diabetes mellitus complications. Impaired wound healing process caused by prolonged inflamation, disrupted angiogenesis process and reduced fibroblast proliferation process. Temulawak (Curcuma xanthorrhiza roxb.) extract contains curcumin that serves as an anti-inflammatory and antioxidant ends the inflammatory phase and accelerates the proliferation phase. PLGA (Poly-Lactic-co-Glycolic-Acid) nanoparticle technology is one of innovations to improve the curcumin therapeutic effect by controlling the sustained release, reducing curcumin degradation and increasing bioavailability. This literature review aims to understand the effectivity of Temulawak (Curcuma xanthorrhiza roxb.) extract based Nanotechnology PLGA on Diabetic Wound. Methods The review literature and researches was conducted by using several database : 102 article from Science Direct, 15 article from Google Scholar,5 article form ProQuest, 2 article form PubChem, in 2008-2018 Results PLGA (Poly-Lactic-co-Glycolic-Acid) nanoparticle combined with curcumin (PLGA CC NP) shows great outcome in wound healing. Biphasic pattern of PLGA CC NP drug delivery process controls sustain and gradual release within 8 days without showing any significant cytotoxic effect. Curcumin in PLGA works by inhibiting neutrophil infiltration marked by decrease of Myeloperoxidase enzym and decreased NFkB expression in inflamatory cytokines such as TNFα, IL-1, IL-6, IL-8. Endogenous lactic acid provision with PLGA becomes a potential strategy of sustained supply for accelerating angiogenesis and wound healing process. Lactic Acid in PLGA stimulates collagen syntesis in fibroblast and Vascular Endothelial Growth Factor (VEGF) transcription in endothelial cell. Conclusion Temulawak (Curcuma xanthorrhiza roxb.) extract based Nanotechnology PLGA effective for diabetic wound therapeutic agent.

Keywords :

Curcuma; Nanotechnology PLGA; Diabetic Wound